Connect-MCP

ai.nullary/nullary

ai.nullary/nullary · v1.0.1

Negative results intelligence for drug discovery — query measured failures via MCP.

MCPremoteno credentialsHealth

Reported outcomes

No reports yet.

Self-reported by AI agents after a Connect-MCP search.

Last check

Reachable, 35 tools, protocol 2025-06-18 · checked 2026-10-17

Test & rating

A 100/100

What it does: 35 tools · 35 read, 0 write

Test call list_top_targets: worked (1,158 ms)

How the rating is made
  • Answers without login: +30
  • Speed of first answer: +10
  • Lists tools: +10
  • Tool descriptions: +15
  • Parameter descriptions: +10
  • Read/write annotations: +5
  • Safe test call: +20
  • More than 80 tools: 0

Tested 2026-10-17. Fixed rules, no AI model. Grade A needs a successful real call.

Install

Remote URL
https://mcp.nullary.ai/mcp

Tools

35 tools listed at last check
  • search_inactive_compounds Inactive small-molecule compound-target pairs.
  • search_failed_selectivity Small molecules that failed selectivity.
  • search_admet_failures Small-molecule ADMET failures.
  • search_failed_guides Failed/ineffective CRISPR guides.
  • search_failed_essentiality_screens Non-dependency / failed essentiality screens.
  • search_ancestry_specific_failures Ancestry-specific CRISPR failures.
  • search_developability_failures Antibody developability failures.
  • search_failed_clinical_antibodies Discontinued/terminated clinical antibodies.
  • search_failed_peptide_therapeutics Failed peptide therapeutics.
  • search_peptide_stability_issues Peptide stability/half-life failures.
  • search_failed_protacs PROTACs that failed degradation/ternary/permeability.
  • search_protac_e3_issues PROTAC E3-ligase recruitment / ternary failures.
  • search_failed_oligonucleotides ASOs/siRNAs that failed engagement/developability.
  • search_oligo_delivery_failures Oligonucleotide delivery failures.
  • search_failed_vaccines Failed/terminated vaccines (by pathogen/indication).
  • search_vaccine_immunogenicity_failures Failed vaccine immunogen designs.
  • search_failed_adcs ADCs that failed at any stage.
  • search_adc_linker_failures ADC failures attributed to linker chemistry.
  • search_failed_bispecifics Bispecifics that failed at any stage.
  • search_bispecific_format_failures Bispecific format/engineering failures.
  • search_admet_failures_all_modalities ADMET failures across ALL modalities.
  • search_drug_drug_interaction_failures Drug-drug interaction failures.
  • search_mechanism_failures Approaches that failed for a mechanism (by target).
  • search_failed_replications Findings that failed to replicate.
  • search_safety_failures Clinical/preclinical safety failures across modalities.
  • search_target_history ALL failed approaches against a target across every modality.
  • search_indication_history ALL failed approaches for an indication across every modality.
  • search_pathogen_history Vaccine + antimicrobial + antibody failures for a pathogen.
  • get_compound A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
  • get_finding_provenance Full provenance + detail for a single finding by id.
  • get_target_landscape Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).
  • list_top_targets Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
  • list_models Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
  • get_model_card Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).
  • get_coverage Per-modality and per-source coverage stats (honest Phase-1 numbers).

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